Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 17;13(1):257. doi: 10.3390/nu13010257

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of nutraceuticals on the stem cell compartment in heart diseases. (A) CoQ10 inhibits high glucose-induced endothelial progenitor cell (EPC) dysfunction and death via modulation of the 5′ adenosine monophosphate-activated protein kinase (AMPK) pathway, upregulating endothelial nitric oxide synthase (eNOS) activity and heme oxygenase-1 (HO-1) expression; (B) oleuropein attenuates AngII-mediated oxidative stress in vascular progenitor cells (VPCs) though direct scavenging activity and regulates the ERK1/2-Prdx and Akt/eNOS signalling pathway; (C) the bergamot polyphenolic fraction (BPF) protects endogenous CSCs against DOXO-induced cardiotoxicity though its direct antioxidant properties and stimulates CSC activation and differentiation in newly formed cardiomyocytes.