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. 2021 Jan 15;22(2):818. doi: 10.3390/ijms22020818

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histological assessment of NAFLD/NASH severity. (A) Representative images of H&E-stained slides of ApoE^(-/-) mice after five weeks of empagliflozin/vehicle oral administration. Lobular inflammation, ballooning cells and cytoplasmic lipid droplets are shown by red, yellow and green arrows, respectively. (B) The liver weight and the ratio of liver weight to body weight. (C) Histological evaluation of steatosis, hepatocellular ballooning, lobular inflammation and NAS score. Data are shown as the mean ± SD (*: p < 0.05).