Table 3.
Relationships between CONUT score and clinicopathological characteristics of 94 HCCA patients
| Variable | CONUTlow (n = 63) | CONUThigh (n = 31) | χ2value | P value |
|---|---|---|---|---|
| Gender | 1.556 | 0.212 | ||
| Male | 30 (47.6%) | 19 (61.3%) | ||
| Female | 33 (52.4%) | 12 (38.7%) | ||
| Age (years) | 0.057 | 0.812 | ||
| <55 | 26 (41.3%) | 12 (38.7%) | ||
| ≥55 | 37 (58.7%) | 19 (61.3%) | ||
| BMI (kg/m2) | 6.788 | 0.034* | ||
| <18.5 | 8 (12.7%) | 11 (35.5%) | ||
| ≥18.5, <25.0 | 38 (60.3%) | 13 (41.9%) | ||
| ≥25.0 | 17 (27.0%) | 7 (22.6%) | ||
| Preoperative TBIL (mg/dl) | 0.928 | 0.335 | ||
| <65.9 | 18 (28.6%) | 6 (19.4%) | ||
| ≥65.9 | 45 (71.4%) | 25 (80.6%) | ||
| Tumor size (cm) | 0.714 | 0.398 | ||
| <2.6 | 26 (41.3%) | 10 (32.3%) | ||
| ≥2.6 | 37 (58.7%) | 21 (67.7%) | ||
| Histopathological type | 0.004 | 0.948 | ||
| Poorly differentiated | 28 (44.4%) | 14 (45.2%) | ||
| medium-high differentiation | 35 (55.6%) | 17 (54.8%) | ||
| Bismuth-Corlette classification | 1.661 | 0.197 | ||
| I-II | 11 (17.5%) | 9 (29.0%) | ||
| III-IV | 52 (82.5%) | 22 (71.0%) | ||
| Hepatic parenchymal invasion | 0.212 | 0.645 | ||
| Positive | 17 (27.0%) | 7 (22.6%) | ||
| Negative | 46 (73.0%) | 24 (77.4%) | ||
| Lymph node metastasis | 1.992 | 0.158 | ||
| Positive | 21(33.3%) | 15 (48.4%) | ||
| Negative | 42 (66.7%) | 16 (51.6%) | ||
| Hepatic artery invasion | 0.178 | 0.673 | ||
| Positive | 10 (15.9%) | 6 (19.4%) | ||
| Negative | 53 (84.1%) | 25(80.6%) | ||
| Portal vein invasion | 1.194 | 0.275 | ||
| Positive | 12 (19.0%) | 9 (29.0%) | ||
| Negative | 51 (81.0%) | 22 (71.0%) | ||
| Perineural invasion | 0.008 | 0.928 | ||
| Positive | 25 (39.7%) | 12 (38.7%) | ||
| Negative | 38 (60.3%) | 19 (61.3%) | ||
| Degree of cure | 8.940 | 0.003* | ||
| R0 | 61 (96.8%) | 2 (3.2%) | ||
| R1 | 23 (74.2%) | 8 (25.8%) | ||
| AJCC stage | ||||
| I-II | 32 (50.8%) | 10 (32.3%) | 2.888 | 0.089 |
| III-IV | 31 (49.2%) | 21 (67.7%) | ||
| Clavien-Dindo classification | ||||
| <IIIa | 54 (85.7%) | 19 (61.3%) | 7.144 | 0.008* |
| ≥IIIa | 9 (14.3%) | 12 (38.7%) | ||
| Bile leakage | ||||
| Presence | 52 (82.5%) | 18 (58.1%) | 6.546 | 0.011* |
| Absence | 11 (17.5%) | 13 (41.9%) |
*Indicates P<0.05. HCCA, Hilar cholangiocarcinoma; BMI, body mass index; TBIL, total bilirubin; AJCC, American Joint Committee on Cancer; CONUT, controlling nutritional status; The cut off value of CONUT score is 3, according to the ROC analyses; R0 resection was confirmed to be negative for both proximal and distal bile duct resection margins by postoperative pathological examination. R1 resection showed no residual tumor in the naked eye, and postoperative pathological examination indicated that the cutting edge of the broken end was positive under the microscope.