Figure 3.

Schematic summary of the regulated expression of WWC proteins and their role in Hippo signaling and cancer. WWC protein activities are controlled at the level of promotor regulation via binding of different transcription factors (TFs) and/or epigenetic DNA methylation (M), miRNA-dependent translation control or specific protein–protein interactions in canonical and non-canonical Hippo signaling. Furthermore, WWC proteins affect alternative pathways, including Wnt signaling or cell polarity-dependent processes, with additional effects on cell proliferation and cancer.