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. 2021 Jan 17;18(2):751. doi: 10.3390/ijerph18020751

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Parallel mediation analysis of aging effects on cognition (MMSE) score through relative HGS (kg) and gait speed (m·seg⁻¹), adjusted by sex, lifestyle, body mass index and comorbidities. Number of bootstrap samples = 5000. The indirect effect is statistically significant at the 95% confidence interval (CI) when the CI does not include 0. Betas (β) are reported as the product of simultaneous regression with bootstrap replacement Path a¹ & a² = association between age and relative HGS and gait speed, respectively; Path b¹ & b² = association between relative HGS and gait speed with cognitive function; Path c = direct effect; orange and blue associations = indirect effect by relative HGS and gait speed, respectively.