Table 1.
Summary results of intervention studies exploring the effect of antiaging and antioxidant strategies.
| Species | Intervention | Results | Reference |
|---|---|---|---|
| Mice | Caloric restriction | Protection of mitochondria in aging heart | Shinmura et al. [414]; Hepple et al. [415] |
| Mice | Resveratrol or caloric restriction | Prevention of age-related cardiac dysfunction | Barger et al. [437] |
| Mice | Nutraceutical combination | Reduction of blood pressure and oxidative stress, improvement of endothelial function and increase of nitric oxide release | Carrizzo et al. [428] |
| Mice | Enalapril and captopril | Enhancement of endogenous antioxidant defenses in mouse tissues | de Cavanagh et al. [452] |
| Mice | CAR-T cell | Elimination of senescent cells and extended survival in lung adenocarcinoma | Amor et al. [481]; [482] |
| Rats | Enalapril | Reduction of oxidative stress in diabetic rats | de Cavanagh et al. [451] |
| Rats | Caloric restriction | Improvement of cardiac aging and diastolic dysfunction in the senescent myocardium | Shinmura et al. [408]; Niemann et al. [407] |
| Rhesus monkeys | Caloric restriction | Delay in age-associated pathologies incidence (diabetes, brain atrophy, cancer, cardiovascular disease) and mortality | Colman et al. [402]; Fowler et al. [404]; McKiernan et al. [406] |
| Humans | Nutraceutical combination | Reduction of blood pressure, increase of nitric oxide release, and improvement of exercise capacity in hypertensive patients | Carrizzo et al. [428] |
| Humans | Caloric restriction or alternate-day fasting | Cardiovascular aging and chronic disease protection | Cruzen et al. [403]; Varady et al. [409] |
| Humans | Polyphenols | Reduction of systolic and diastolic blood pressure in high cardiovascular risk population | Medina-Remón et al. [425] |
| Humans | Dietary supplements, fish oil, green tea extract, resveratrol, vitamin E, vitamin C, and tomato extract | Improvement of endothelial function, reduction of inflammation and oxidative stress | Bakker et al. [426]; Schwingshackl et al. [434] |
| Humans | Resveratrol | Reduction of oxidative stress and endothelial dysfunction in hypertensive patients | Carrizzo et al. [436]; |
| Humans | Rapamycin | Reduction of senescent markers in patients with coronary artery disease | Singh et al. [475]; Krebs et al. [476] |