Figure 1.

Colony morphology and bacterial abundance in C57BL/6 mice 1, 7, and 14 dpi. (A) Picture of a smooth (S) Mab colony cultured 5 days at 37 °C on agar plates showing a circular shape and a moist appearance; (C) Rough (R) Mab colony with rugged edges and dry appearance. Mice were infected with high (10⁷ CFUs) and low (10⁴ CFUs) of (B) S (3044) and (D) R (3492) Mab by intranasal infection. The right lung was collected from four mice per timepoint, and lysates were plated on agarose media. Average bacterial load decreased from 1 to 14 days postinfection (dpi) for each morphotype and dose.