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. 2021 Jan 16;9(1):81. doi: 10.3390/biomedicines9010081

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Confocal microscope imaging for assessing the uptake of sulfo-cyanine 7.5-labeled milk exosomes (SCy-MiExo) by hepatocytes. (A,B) Near infrared (NIR, top) and fluorescence images (bottom) taken over time as hepatocytes internalized: (A) 5 µg/mL and (B); 0.5 µg/mL of SCy-MiExo; (C) Quantification of the exosome uptake at different SCy-MiExo concentrations, analyzed in regions of interest. Values were statistically significant between both concentration at 24 h; **** (p ≤ 0.0001). Data are expressed as the mean ± standard deviation. (D) Statistical analysis for the dose of 5 µg/mL: all values were significant compare to 24 h; * (p ≤ 0.05), ** (p ≤ 0.01), *** (p ≤ 0.001), **** (p ≤ 0.0001). (E) Statistical analysis for the dose of 0.5 µg/mL; * (p ≤ 0.05), ** (p ≤ 0.01), *** (p ≤ 0.001), **** (p ≤ 0.0001).