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. 2021 Jan 16;9(1):81. doi: 10.3390/biomedicines9010081

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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In vivo and ex vivo studies with SCy-MiExo: (A) In vivo optical imaging of sulfo-cyanine 7.5-labeled milk exosomes (SCy-MiExo, top) and free SCy 7.5 (bottom) in healthy mice. (B) The time course of average radiant efficiency measured in vivo in livers of mice treated with SCy-MiExo. The data are expressed as the % (graph) and in units of p/s/cm²/sr)/(μW/cm²) (table), with the mean ± standard deviation. (C) Ex vivo biodistribution of SCy-MiExo (left) and free SCy 7.5 (right) in excised organs. (D) Confocal images of liver sections from mice treated with SCy-MiExo. Right down image presents a zoom of left down image. (E) Hematoxylin and Eosin (H&E) histological images of liver sections from mice treated with SCy-MiExo.