Table 1.
Target and spotting concentration of single chain fragment variable (scFv), with typical biomarker concentrations in patients.
| ScFv | Target Biomarker | Spotting scFv Conc. (mg/mL) | Typical biomarker Concentration (pg/mL) |
|---|---|---|---|
| PC013 | Interleukin-5 (IL-5) | 0.111 | ~10 (asthmatic) [33] ~1 (healthy) [36] |
| PC070 | Monocyte chemoattractant protein (MCP-1) | 0.139 | ~5 × 102 (diabetic) [37] ~4 × 102 (ischemic stroke) [34] ~102 (healthy) [38] |
| RD003 | Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) | 0.300 | ~ 5 × 105 (lung cancer) [31] ~1.5 × 105 (melanoma) [39] ~6 × 105 (healthy) [40] |
| RD004 | Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) | 0.300 | |
| RD017 | Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) | 0.230 | Large dynamic range reported: ~102 (cancer patients) [41] ~2 × 103 (primary proliferative glomerulonephritides) [42] |