Table 4.

Differentially methylated regions (DMRs) in children PBMCs at 5 years associated with IgE sensitization to food allergens at 5 years.

Chr	Start	End	Width bp	Number of CpGs	Gene Name	Location	T	Z p-Value	Z Sidak p-Value
DMRs detected with increased DNA methylation levels in children sensitized to food allergens
chr10	135,278,717	135,279,148	432	5	SCART1	Promoter	1.63	1.4 × 10−10	1.4 × 10−7
chr19	37,825,307	37,825,680	374	7	HKR1	Promoter	2.40	1.6 × 10−8	0.000019
chr1	1,108,820	1,109,984	1165	8	TTLL10	Promoter	2.65	7.1 × 10−8	0.000027
chr4	74,847,646	74,847,830	185	7	PF4	Promoter	2.82	1.4 × 10−8	0.00003
chr13	88,328,009	88,328,295	287	4	SLITRK5	Exon	1.67	9.3 × 10−8	0.0001
chr13	26,586,254	26,587,012	759	7	ATP8A2	Exon	1.91	3.6 × 10−7	0.0002
chr8	70,980,488	70,981,069	582	3	PRDM14	Exon	0.54	2.7 × 10−7	0.0002
chr16	86,766,712	86,768,118	1407	6	LINC02188 *	Intergenic	1.59	1.1 × 10−6	0.0003
chr10	99,338,056	99,338,241	186	4	ANKRD2	Exon	1.18	2.1 × 10−7	0.0005
chr1	3,774,827	3,775,207	381	6	DFFB	Promoter	1.34	7.0 × 10−7	0.0008
chr6	39,760,607	39,761,596	990	6	DAAM2	Promoter	0.92	0.000002	0.0010
DMRs detected with reduced DNA methylation levels in children sensitized to food allergens
chr10	128,810,484	128,810,905	422	3	DOCK1	Exon	−2.54	1.2 × 10−6	0.0013
chr17	72,462,417	72,463,081	665	6	CD300A	Promoter	−2.28	5.8 × 10−6	0.0038
chr17	75,315,486	75,315,668	183	6	SEPT9	Promoter	−1.70	1.2 × 10−6	0.0028
chr15	45,670,865	45,671,196	332	10	GATM	Promoter	−1.69	1.2 × 10−5	0.016
chr11	1,463,541	1,463,663	123	4	BRSK2	Promoter	−1.58	1.0 × 10−5	0.038
chr17	7,591,564	7,591,948	385	9	WRAP53	Promoter	−1.27	1.4 × 10−5	0.016
chr19	49,223,814	49,224,166	353	5	RASIP1	3′ UTR	−1.13	4.1 × 10−5	0.049
chr3	149,469,835	149,470,420	586	7	COMMD2	Promoter	−1.12	3.6 × 10−5	0.026
chr7	157,809,235	157,809,597	363	5	PTPRN2	Intron	−1.01	3.6 × 10−5	0.042
chr2	179,387,853	179,388,065	213	3	TTN-AS1 MIR548N	Promoter	−0.7	7.3 × 10−7	0.0015

* Gene with the closest transcription start site to the DMR. Chr = chromosome; bp = base pair.