Table 12.
Treatment-related potential prognostic factors for local and peritoneal recurrence
|
|
Recurrence, n = 58
|
|||||||
|
Peritoneal
|
Local
|
|||||||
|
No, n = 51 (87.9%)
|
Yes, n = 7 (12.1%)
|
HR (95%CI)
|
P
value
|
No, n = 41 (70.7)
|
Yes, n = 17 (29.3)
|
HR (95%CI)
|
P
value
|
|
| Neoadjuvant therapy, n (%) | 0.569 | 0.475 | ||||||
| No | 23 (82.1) | 5 (17.9) | Reference | 23 (81.1) | 5 (17.9) | Reference | ||
| Yes | 2 (100) | 0 (0) | 2.71 (0.09-84.27) | 2 (100) | 0 (0) | 3.88 (0.09-160.22) | ||
| Missing | 26 | 2 | 16 | 12 | ||||
| Surgery, n (%) | ||||||||
| Right emicolectomy | 10 (83.3) | 2 (16.7) | Reference | 6 (50) | 6 (50) | Reference | ||
| Extended right emicolectomy | 3 (100) | 0 (0) | 0.23 (0.01-11.90) | 0.468 | 2 (66.7) | 1 (33.3) | 0.20 (0.02-1.68) | 0.140 |
| Intermediate colectomy | 4 (100) | 0 (0) | 1.20 (0.03-47.50) | 0.923 | 4 (100) | 0 (0) | 0.35 (0.01-8.18) | 0.511 |
| AR/Hartmann’s procedure | 23 (92) | 2 (8) | 0.36 (0.04-3.04) | 0.350 | 17 (68) | 8 (32) | 0.41 (0.13-1.29) | 0.127 |
| Low Anterior resection/Miles | 8 (80) | 2 (20) | 0.68 (0.07-6.27) | 0.731 | 9 (90) | 1 (10) | 0.15 (0.02-1.07) | 0.059 |
| Total/Sub-total colectomy | 2 (66.7) | 1 (33.3) | 2.99 (0.25-35.10) | 0.383 | 2 (66.7) | 1 (33.3) | 0.98 (0.14-6.95) | 0.981 |
| Segmental resection | 1 (100) | 0 (0) | - | - | 1 (100) | 0 (0) | - | - |
| Associated procedure, n (%) | ||||||||
| No | 11 (91.7) | 1 (8.3) | Reference | 11 (91.7) | 1 (8.3) | Reference | ||
| Minor | 11 (84.6) | 2 (15.4) | 1.16 (0.10-14.11) | 0.905 | 7 (53.8) | 6 (46.2) | 2.41 (0.33-17.37) | 0.384 |
| Major | 7 (100) | 0 (0) | 0.61 (0.01-31.26) | 0.808 | 5 (71.4) | 2 (28.6) | 3.26 (0.36-29.71) | 0.295 |
| Missing | 22 | 4 | 18 | 8 | ||||
| Operative technique, n (%) | 0.128 | 0.368 | ||||||
| Open | 35 (94.6) | 2 (5.4) | Reference | 25 (67.6) | 12 (32.4) | Reference | ||
| Laparoscopy | 16 (76.2) | 5 (23.8) | 3.64 (0.69-19.14) | 16 (76.2) | 5 (23.8) | 0.61 (0.21-1.77) | ||
| Duration of surgery, min, mean ± SD | 239 ± 85 | 249 ± 87 | 1.00 (0.99-1.01) | 0.869 | 244 ± 81 | 232 ± 93 | 1.00 (0.99-1.01) | 0.934 |
| Hospital stay, d, mean ± SD | 9.8 ± 3.2 | 10.0 ± 4.1 | 0.98 (0.76-1.27) | 0.907 | 9.4 ± 3.3 | 10.7 ± 3.1 | 1.09 (0.96-1.23) | 0.181 |
| Postoperative blood transfusion, n (%) | 0.272 | 0.518 | ||||||
| No | 37 (92.5) | 3 (7.5) | Reference | 30 (75) | 10 (25) | Reference | ||
| Yes | 13 (76.5) | 4 (23.5) | 2.32 (0.52-10.38) | 10 (58.8) | 7 (41.2) | 1.39 (0.51-3.74) | ||
| Missing | 1 | - | 1 | - | ||||
| Reoperation due to complications, n (%) | 0.344 | 0.182 | ||||||
| No | 17 (81) | 4 (19) | Reference | 18 (75) | 6 (25) | Reference | ||
| Yes | 1 (50) | 1 (50) | 3.00 (0.31-29.24) | 1 (50) | 1 (50) | 4.35 (0.50-37.59) | ||
| Missing | 33 | 2 | 22 | 10 | ||||
| Adjuvant therapy, n (%) | 0.481 | 0.852 | ||||||
| No | 20 (90.9) | 2 (9.1) | Reference | 14 (63.6) | 8 (36.4) | Reference | ||
| Yes | 28 (90.3) | 3 (9.7) | 2.26 (0.23-21.77) | 23 (74.2) | 8 (25.8) | 1.11 (0.38-3.21) | ||
| Missing | 3 | 2 | 4 | 1 | ||||
| Start of adj chemotherapy, n (%) | 0.648 | 0.953 | ||||||
| < 6 wk from surgery | 12 (92.3) | 1 (7.7) | Reference | 9 (69.2) | 4 (30.8) | Reference | ||
| ≥ 6 wk from surgery | 8 (88.8) | 1 (11.1) | 1.91 (0.12-30.85) | 7 (77.8) | 2 (22.2) | 0.95 (0.18-5.13) | ||
| Missing | 31 | 5 | 25 | 1 | ||||
HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals; Adj: Adjuvant.