Table 4.
Demographic and patient-related preoperative potential prognostic factors for recurrence and evaluation of early vs late recurrence (univariate analysis)
|
Recurrence, n = 234
|
Timing of recurrence, n = 60
|
||||||||
|
All
|
No
|
Yes
|
HR (95%CI)
|
P
value
|
Early recurrence (< 3 yr)
|
Late recurrence (≥ 3 yr)
|
OR (95%CI)
|
P
value
|
|
|
n
(%)
|
n
= 174 (67.7%)
|
n
= 60 (23.3%)
|
n
= 51 (85.0%)
|
n
= 9 (15.0%)
|
|||||
| Age, yr; mean ± SD | 68 ± 12 | 68 ± 11 | 69 ± 12 | 1.00 (0.98-1.02) | 0.868 | 67 ± 12 | 77 ± 8 | 1.10 (1.00-1.21) | 0.050 |
| Gender, n (%) | 0.179 | 0.421 | |||||||
| Male | 128 (54.7) | 99 (77.3) | 29 (22.6) | Reference | 25 (86.2) | 4 (13.8) | Reference | ||
| Female | 106 (45.3) | 75 (70.7) | 31 (29.2) | 1.42 (0.85-2.37) | 26 (83.9) | 5 (16.1) | 1.85 (0.41-8.21) | ||
| Preop Hb, g/dL, mean ± SD | 12.3 ± 2.1 | 12.6 ± 2.1 | 11.6 ± 2.3 | 0.84 (0.71-1.01) | 0.058 | 11.9 ± 2.2 | 9.67 ± 2.3 | 0.60 (0.31-1.17) | 0.136 |
| Preop glycemia, g/dL, mean ± SD | 0.99 ± 0.26 | 0.96 ± 0.24 | 1.08 ± 0.31 | 3.44 (1.05-11.24) | 0.040 | 1.10 ± 0.34 | 0.99 ± 0.19 | 0.25 (0.00-16.06) | 0.518 |
| Preop total proteins, g/dL, mean ± SD | 6.8 ± 0.7 | 6.8 ± 0.6 | 6.8 ± 1 | 1.07 (0.54-2.11) | 0.839 | 6.7 ± 1.0 | 7.3 ± 0.2 | 2.43 (0.47-12.54) | 0.288 |
| Preop CEA, n (%) | 0.029 | 0.440 | |||||||
| < 5 ng/mL | 85 (82.5) | 71 (83.5) | 14 (16.5) | 0.36 (0.15-0.90) | 12 (85.7) | 2 (14.3) | Reference | ||
| ≥ 5 ng/mL | 18 (17.5) | 11 (61.1) | 7 (38.9) | Reference | 5 (71.4) | 2 (28.6) | 2.40 (0.26-22.10) | ||
| Missing | 131 | 131 | 39 | ||||||
| BMI, mean ± SD | 26 ± 4 | 25 ± 4 | 27 ± 5 | 1.06 (0.99-1.14) | 0.085 | 27 ± 5 | 27 ± 5 | 0.98 (0.81-1.19) | 0.866 |
| ASA, n (%) | |||||||||
| 1 | 31 (14.5) | 26 (83.9) | 5 (16.1) | Reference | 5 (100) | 0 (0) | Reference | ||
| 2 | 80 (37.4) | 61 (76.2) | 19 (23.8) | 1.50 (0.56-4.02) | 0.421 | 16 (84.2) | 3 (15.8) | - | 0.951 |
| 3 | 94 (43.9) | 72 (76.6) | 22 (23.4) | 1.51 (0.57-3.40) | 0.404 | 16 (72.7) | 6 (27.3) | - | 0.948 |
| 4 | 9 (4.2) | 5 (55.6) | 4 (44.4) | 3.85 (1.03-14.41) | 0.045 | 4 (100) | 0 (0) | - | 1.000 |
| Missing | 20 | 20 | 10 | ||||||
| Presentation with occlusion, n (%) | 0.021 | 0.366 | |||||||
| No | 42 (59.2) | 33 (78.6) | 9 (21.4) | Reference | 7 (77.8) | 2 (22.2) | Reference | ||
| Yes | 29 (40.8) | 15 (51.7) | 14 (48.3) | 2.60 (1.15-5.87) | 13 (92.9) | 1 (7.1) | 0.31 (0.02-3.97) | ||
| Missing | 163 | 163 | 37 | ||||||
| Tumor site, n (%) | |||||||||
| Right colon | 70 (29.9) | 53 (75.7) | 17 (24.3) | Reference | 13 (76.5) | 4 (23.5) | Reference | ||
| Left colon | 103 (44) | 76 (73.8) | 27 (26.2) | 0.93 (0.50-1.70) | 0.807 | 24 (88.9) | 3 (11.1) | 0.41 (0.08-2.10) | 0.282 |
| Rectum | 61 (26.1) | 45 (73.8) | 16 (26.2) | 0.94 (0.47-1.85) | 0.851 | 14 (87.5) | 2 (12.5) | 0.46 (0.07-2.98) | 0.418 |
HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals; Preop: Preoperative value; Hb: Haemoglobin; CEA: Carcinoembryonic antigen; BMI: Body mass index; ASA: American Society of Anaesthesiologists Score.