Table 5.
Treatment-related potential prognostic factors for recurrence and evaluation of early versus late recurrence (univariate analysis)
|
Recurrence, n = 234
|
Timing of recurrence, n = 60
|
||||||||
|
All
|
No
|
Yes
|
HR (95%CI)
|
P
value
|
Early recurrence (< 3 yr)
|
Late recurrence (≥ 3 yr)
|
OR (95%CI)
|
P
value
|
|
|
n
, %
|
n
= 174 (67.7%)
|
n
= 60 (23.3%)
|
n
= 51 (85.0%)
|
n
= 9 (15.0%)
|
|||||
| Neoadjuvant therapy, n (%) | 0.921 | 0.949 | |||||||
| No | 97 (93.3) | 68 (70) | 29 (30) | Reference | 25 (86.2) | 4 (13.8) | Reference | ||
| Yes | 7 (6.7) | 5 (71) | 2 (29) | 1.07 (0.26-4.51) | 2 (100) | 0 (0) | 1.13 (0.02-53.57) | ||
| Missing | 130 | 130 | 29 | ||||||
| Surgery, n (%) | |||||||||
| Right emicolectomy | 55 (23.5) | 42 (76.4) | 13 (23.6) | Reference | 10 (76.9) | 3 (23.1) | Reference | ||
| Extended right emicolectomy | 15 (6.4) | 12 (80) | 3 (20) | 1.16 (0.37-3.59) | 0.801 | 2 (66.7) | 1 (33.3) | 4.20 (0.37-47.64) | 0.247 |
| Intermediate colectomy | 10 (4.3) | 6 (60) | 4 (40) | 2.16 (0.70-6.71) | 0.182 | 3 (75) | 1 (25) | 1.80 (0.14-23.6) | 0.655 |
| AR/Hartmann | 106 (45.3) | 80 (75.5) | 26 (24.5) | 1.09 (0.55-2.17) | 0.798 | 24 (92.3) | 2 (7.7) | 0.43 (0.06-3.02) | 0.395 |
| LAR/Miles | 38 (16.2) | 28 (73.7) | 10 (26.3) | 1.16 (0.50-2.68) | 0.731 | 8 (80) | 2 (20) | 1.23 (0.16-9.69) | 0.841 |
| Total/Sub-total Colectomy | 6 (2.6) | 3 (50) | 3 (50) | 2.69 (0.76-9.53) | 0.126 | 3 (100) | 0 (0.0) | 0.60 (0.01-24.50) | 0.787 |
| Segmental resection | 4 (1.7) | 3 (75) | 1 (25) | 1.12 (0.14-8.68) | 0.916 | 1 (100) | 0 (0.0) | 1.7 (0.02-162.35) | 0.819 |
| Associated procedure, n (%) | |||||||||
| No | 52 (50.5) | 39 (75) | 13 (25) | Reference | 11 (84.6) | 2 (15.4) | Reference | ||
| Minor | 40 (38.8) | 27 (67.5) | 13 (32.5) | 1.30 (0.60-2.80) | 0.505 | 11 (84.6) | 2 (15.4) | 1.00 (0.13-7.44) | 1.00 |
| Major | 11 (10.7) | 4 (36.4) | 7 (63.6) | 3.56 (1.41-8.96) | 0.007 | 7 (100) | 0 (0) | 0.31 (0.01-8.95) | 0.492 |
| Missing | 131 | 131 | 27 | ||||||
| Operative technique, n (%) | < 0.001 | 0.061 | |||||||
| Open | 99 (42.7) | 61 (61.6) | 38 (38.4) | Reference | 35 (92.1) | 3 (7.9) | Reference | ||
| Laparoscopy | 133 (57.3) | 111 (83.5) | 22 (16.5) | 0.37 (0.22-0.62) | 16 (72.7) | 6 (27.3) | 4.00 (0.94-17.01) | ||
| Missing | 2 | 2 | - | ||||||
| Duration of surgery, min – mean ± SD | 232 ± 67 | 230 ± 61 | 239 ± 83 | 1.00 (0.99-1.01) | 0.496 | 238 ± 78 | 242 ± 112 | 1.00 (0.99-1.01) | 0.808 |
| Postop blood transfusion, n (%) | 0.123 | 0.119 | |||||||
| No | 174 (75.7) | 134 (77) | 40 (23) | Reference | 36 (90) | 4 (10) | Reference | ||
| Yes | 56 (24.3) | 37 (66.1) | 19 (33.9) | 1.54 (0.89-2.66) | 14 (73.7) | 5 (26.3) | 3.08 (0.75-12.64) | ||
| Missing | 4 | 4 | 1 | ||||||
| Reoperation, n (%) | 0.262 | 0.559 | |||||||
| No | 82 (91.1) | 60 (73.2) | 22 (26.8) | Reference | 17 (77.3) | 5 (22.7) | Reference | ||
| Yes | 8 (8.9) | 5 (62.5) | 3 (37.5) | 1.99 (0.60-6.61) | 2 (66.7) | 1 (33.3) | 2.13 (0.17-26.68) | ||
| Missing | 144 | 144 | 35 | ||||||
| Hospital stay, d, mean ± SD | 9.2 ± 6 | 8.7 ± 3.7 | 10.9 ± 9.1 | 1.05 (1.02-1.07) | 0.001 | 10.9 ± 9.8 | 10.6 ± 4.0 | 1.01 (0.95-1.08) | 0.737 |
| Adjuvant therapy, n (%) | 0.064 | 0.057 | |||||||
| No | 127 (56.4) | 103 (81.1) | 24 (18.9) | Reference | 18 (75) | 6 (25) | Reference | ||
| Yes | 98 (43.5) | 67 (68.4) | 31 (31.6) | 1.65 (0.97-2.81) | 28 (90.3) | 3 (9.7) | 0.22 (0.04-1.04) | ||
| Missing | 9 | 9 | 5 | ||||||
| Start of adj CHT, n (%) | 0.268 | 0.401 | |||||||
| < 6 wk | 26 (48.1) | 13 (50) | 13 (50) | Reference | 12 (92.3) | 1 (7.7) | Reference | ||
| ≥ 6 wk | 28 (51.9) | 19 (67.9) | 9 (32.1) | 1.63 (0.69-3.95) | 8 (88.9) | 1 (11.1) | 4.4 (0.14-141.01) | ||
| Missing | 180 | 180 | 38 | ||||||
HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals; AR: Anterior resection of the rectum; LAR: Low anterior resection of the rectum; Adj CHT: Adjuvant chemotherapy.