Tab. 2.

Hyaluronic acid-based fillers for lip augmentation in adults and lip wrinkle reduction approved by the U.S. Food and Drug Administration

Date of approval	Product/manufacturer	Material	Indications
2020	Restylane Kysse / Galderma Laboratories, LP	20 mg/ml; HA, 0.3% lidocaine	lip augmentation, lip wrinkles
2016	Juvéderm Volbella XC / Allergan, Inc	15 mg/ml; HA, 0.3% lidocaine	lip augmentation, lip wrinkles
2015	Juvéderm Ultra XC / Allergan, Inc	24 mg/ml; HA, 0.3% lidocaine	lip augmentation, lip wrinkles
2014	Restylane Silk / Galderma Laboratories, LP	20 mg/ml; HA, 0.3% lidocaine	lip augmentation, lip wrinkles
2012	Restylane-L / Galderma Laboratories, LP	20 mg/ml; HA, 0.3% lidocaine	lip augmentation, lip wrinkles
2011	Belotero Balance / Merz Aesthetics	22.5 mg/ml; HA	lip wrinkles
2011	Restylane / Galderma Laboratories, LP	20 mg/ml; HA	lip augmentation, lip wrinkles

HA – hyaluronic acid