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. 2021 Jan 15;12(1):101. doi: 10.3390/genes12010101

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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fzd1, fzd4-1, and lrp5/6 are expressed in posteriors blastemas after amputation. (A) Whole-mount in situ hybridization (WISH) of fz1, fzd4-1, and lrp5/6 in intact animals and at 48 h of regeneration (48 hR), showing its presence in posterior blastemas (blue arrows). Blue shadows in the schematic cartoons represent the studied regenerative pieces: heads and trunks. Scale bar: 100 µm. (B) The phylogenetic tree based on LRP sequences (Table S1) showed that lrp5, lrp6, and lrp5/6 genes cluster together. At nodes, values for the approximate Bayes (square) and Likelihood (circle) ratio tests are shown. Colour indicates % of confidence. Dark asterisks indicate Schmidtea mediterranea (Smed) genes. Scale indicates expected aminoacidic substitution per site. The following species were used: Homo sapiens (Hsap), Xenopus tropicals (Xtro), Branchiostoma floridae (Bflo), Saccoglossus kowalewski (Sko), Crassostrea gigas (Cgig), Octopus bimaculoides (Obim), Schistosoma mansoni (Sman), Nematostella vectensis (Nvec), and Amphimedon queenslandica (Amq).