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. 2021 Jan 18;13(1):125. doi: 10.3390/v13010125

Figure 2.

Figure 2

HIV-1 CA, capsomere, and capsid shell structures. (A) The structure of the CA monomer from protein data bank (PDB) entrant 4XFY [29] is color-coded to highlight the N-terminal domain (NTD) (residues 1–146; light blue), interdomain linker (residues 147–149; magenta), and C-terminal domain (CTD) (residues 150–231; dark blue). Labels demarcate secondary structural elements. The host factor cyclophilin A (CypA) engages CA via the CypA-binding loop [30]. (B) The hexameric capsomere from PDB entrant 4U0D [31]. The upper “top” view represents what would be seen from the outer surface of the core shell. Rotating this view 90° into the plane of the page yields the lower “side” view. Coloring is maintained from panel A. (C) The pentameric capsomere (PDB code 3P05) [32]. Upper and lower images are analogous to those in panel B. Orange is used to highlight NTDs of pentameric capsomeres; other coloring is same as panel A. (D) Atomic model of assembled core shell (PDB code 3J3Y). The model is composed of 186 hexameric capsomeres and 12 pentamers [33]. Coloring is same as in panels A–C.