Figure 2.

The combination of VIT-2763 and DFX ameliorated anemia and ineffective erythropoiesis in Hbb^th3/+ mice. VIT-2763 alone or in combination with DFX significantly increased hemoglobin levels (a), red blood cell (RBC) counts (b), hematocrit (c), and mean corpuscular hemoglobin concentration (MCHC) (d), and significantly reduced mean corpuscular volume (MCV) (e), mean corpuscular hemoglobin (MCH) (f), and reticulocyte counts (g). DFX alone had no effect. Results represent the mean ± SD. Statistical significance was determined using one-way ANOVA with Dunnett’s multiple-comparison test. * p < 0.05, ** p < 0.01, and *** p < 0.001. Wild-type (WT) littermates received both vehicles and were included as controls. n = 10–13 mice per group.