Skip to main content
. 2021 Jan 16;22(2):873. doi: 10.3390/ijms22020873

Figure 3.

Figure 3

VIT-2763 alone or in combination with DFX improved erythropoiesis in Hbbth3/+ mice. (a) Splenomegaly was significantly reduced in Hbbth3/+ mice treated with VIT-2763 alone or in combination with DFX compared to Hbbth3/+ mice treated with vehicle or DFX alone. (b) Elevated erythropoietin (EPO) levels were significantly corrected in mice treated with VIT-2763 alone or in combination with DFX. (c–e) VIT-2763 decreased the frequency of polychromatic erythroblasts (c,e populations in gate 3) and increased the proportion of mature erythrocytes (d,e populations in gate 5) in the spleen. Representative dot plots are shown in (e). Results represent the mean ± SD. Statistical significance was determined using one-way ANOVA with Dunnett’s multiple-comparison test. ** p < 0.01, and *** p < 0.001. Wild-type (WT) littermates received both vehicles and were included as controls. (a,b) n = 10–13 mice per group; (c–e) n = 5–6 mice per group.