Figure 1.

Effects of anesthetic doses on baseline blood oxygen level dependent (BOLD) signal, responses to peripheral and central stimulation and functional connectivity in rats and mice. Yes = differences between doses were clearly observed; partial = differences between doses were observed for some outcomes, analyses or animals, but not consistently, or quantitative differences were reported, but statistical significance unclear; and no = no differences between doses were observed. When datasets were re-analyzed, findings were pooled and one data point per specific comparison (i.e., per anesthetic per type of functional magnetic resonance imaging (fMRI)) displayed. (dex)medetomidine = medetomidine or dexmedetomidine was studied. (S-)ketamine = ketamine or S-ketamine was studied. Not all references are discussed in the text [43,44], but a summary of the main findings as well as the doses of anesthetics are provided for references with the symbols ■ or □ in Supplementary Materials Tables S2 and S5, with symbols ● or ○ in Supplementary Materials Tables S3 and S5, and for references with symbol ★ in Supplementary Materials Tables S4 and S6.