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. 2021 Jan 11;11:624657. doi: 10.3389/fphys.2020.624657

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Copyright © 2021 Arnardottir, Pawelzik, Öhlund Wistbacka, Artiach, Hofmann, Reinholdsson, Braunschweig, Tornvall, Religa and Bäck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic study protocol for the COVID-Omega-F trial, registered in the European Union Drug Regulating Authorities Clinical Trials (EudraCT) database with number 2020-002293-28 and at ClinicalTrials.gov (clinicaltrials.gov/ct2/show/NCT04647604). An intravenous omega-3 PUFA emulsion (n-3) is compared with placebo (NaCl) for effects on a panel of inflammatory biomarkers; white blood cells (WBC), C-reactive protein (CRP), cytokines and lipid mediators at the end of the treatment period. Secondary endpoints include changes in specialized proresolving mediators (SPMs), fatty acids, cardiac markers, lactate dehydrogenase (LD), D-dimer, fribronogen (Fg), and infectious load. National Early Warning Score 2 (NEWS2), length of hospital stay, intensive cae unit (ICU) need, and mortality will be monitored for a descriptive analysis. The inclusion criteria for COVID-Omega-F comprise female and male patients ≥18 years of age diagnosed with COVID-19 and presenting with a clinical status requiring hospitalization. Exclusion criteria are defined according to i.v. omega-3 PUFA emulsion contraindications, known hypersensitivity, participation in other clinical research study, pregnancy, and breastfeeding.