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Antimicrobial activity and hemolytic activity of N-terminal fatty acylated peptides.
| Peptide | Sequence | MIC (µM) | Hemolysis (µM) | |||
|---|---|---|---|---|---|---|
| Gram Positive | Gram Negative | |||||
| S.a. | E.c. (DH5α) | P.a. | MDRP | |||
| 2 | H-S5IKKS5LKSAKKFVKAFK-NH2 | 3.125 | 1.56 | 1.56 | 1.56 | 50 |
| C6-2 | CH3(CH2)4CO-S5IKKS5LKSAKKFVKAFK-NH2 | 1.56 | 1.56 | 3.125 | 3.125 | 12.5 |
| C12-2 | CH3(CH2)10CO-S5IKKS5LKSAKKFVKAFK-NH2 | 6.25 | 6.25 | 12.5 | 25 | 0.78 |
| C18-2 | CH3(CH2)16CO-S5IKKS5LKSAKKFVKAFK-NH2 | >50 | >50 | >50 | >50 | 0.78 |
