Figure 2.

Response to intensified B-depletion therapy (IBCDT) related to systemic sclerosis (SSc) disease duration. Patients are divided in two groups according to the overall response to IBCDT in at least 2 SSc-domains (Modified Rodnan Skin Score, high resolution computed tomography lung, pulmonary function tests, N-terminal-pro-brain natriuretic peptide). Mean disease duration is significantly shorter in those patients who experienced a response to IBCDT in two or more SSc-domains (mean disease duration 4.2 years vs. 10.125 years). Y axis: Years, years of diseases duration (from diagnosis). Results are presented as mean ± standard error of the mean (SEM).