Table 2.
Clinical profile during the follow-up.
| Baseline | 24 Months | p-Value * | 36 Months | p-Value ** | |
|---|---|---|---|---|---|
| Rodnan Skin Score | 14.4 ± 10.5 | 12.9 ± 10 | p = 0.073 | 11.9 ± 9 | p < 0.05 |
| NT-proBNP (mean ± SD, pg/mL) | 385.4 ± 517 | 283 ± 648 | p < 0.05 | 279 ± 543 | p < 0.05 |
| FVC (mean ± SD) | 93.6 ± 19.3 | 92.2 ± 23.3 | p = 0.77 | 91.2 ± 22.7 | p = 0.63 |
| FEV1 (mean ± SD) | 89.5 ± 15.6 | 87 ± 21.2 | p = 0.59 | 88 ± 23.1 | p = 0.57 |
| DLCO | 58.8 ± 8.6 | 60.3 ± 14 | p = 0.71 | 59.9 ± 13.2 | p = 0.77 |
| Ejection fraction (mean ± SD) | 62.8 ± 6.4 | 58.6 ± 7.1 | p = 0.45 | 59.5 ± 7.9 | p = 0.34 |
| pulmonary artery pressure (mean ± SD) | 30.2 ± 10.5 | 31.1 ± 11.05 | p = 0.51 | 32.2 ± 12.1 | p = 0.49 |
| eGFR (mL/min/1.73 m2) | 71.4 ± 9.7 | 72.3 ± 10.6 | p = 0.75 | 70.2 ± 11.3 | p = 0.71 |
* Comparing baseline and 24-month follow-up; ** comparing baseline and 36-month follow-up; Student’s t-test was used for normally distributed parameters and the non-parametric Mann–Whitney test for non-normally distributed parameters. p < 0.05 was considered statistically significant.NT-proBNP, N-terminal-pro-brain natriuretic peptide; FVC, forced vital capacity, FEV1, forced expiratory volume in one second; DLCO, diffusing capacity for carbon monoxide; eGFR, Estimated glomerular filtration rate.