Table 3.
Cerebrospinal fluid biomarkers data of cohort based on presumed underlying proteinopathy.
| I. Classical CSF AD Biomarkers | |||
|
Synucleinopathies
n = 22 |
Tauopathies
n = 22 |
p-Value | |
| τT (pg/mL) | 246 (184–309) |
278 (192–359) |
<0.799 * |
| Aβ42 (pg/mL) | 696 (576–895) |
774 (557–895) |
<0.916 * |
| τP-181 (pg/mL) | 37 (30–46) |
43 (28–55) |
<0.873 * |
| τT/Aβ42 | 0.31 (0.29–0.38) |
0.39 (0.31–0.45) |
<0.175 ‡ |
| τP-181/τT | 0.15 (0.12–0.17) |
0.14 (0.14–0.16) |
<0.918 ‡ |
| t-α-syn (pg/mL) | 632 (509–837) |
883 (605–1124) |
0.034 ‡ |
| pS129-α-syn (pg/mL) | 64 (46–105) |
65 (53–95) |
0.819 * |
| II. CSF α-syn Species in All Patients | |||
|
Synucleinopathies
n = 22 |
Tauopathies
n = 22 |
||
| o-α-syn (pg/mL) | 72.5 (62–85) |
76 (62–98) |
0.681 ‡ |
| pS129-α-syn/t-α-syn | 0.13 (0.07–0.18) |
0.08 (0.05–0.12) |
0.119 ‡ |
| ο-α-syn/t-α-syn | 0.12 (0.08–0.15) |
0.08 (0.06–0.13) |
0.116 * |
| III. CSF α-syn Species after Exclusion of Patients with Blood Contamination | |||
|
Synucleinopathies
n = 17 |
Tauopathies
n = 13 |
||
| t-α-syn (pg/mL) | 591 (455–791) |
1022 (776–1124) |
0.002 |
| pS129-α syn (pg/mL) | 81 (52–110) |
63 (57–73) |
0.711 |
| o-α-syn (pg/mL) | 67 (60–77) |
75 (70–98) |
0.229 |
| pS129-α-syn/t-α-syn | 0.15 (0.09–0.18) |
0.07 (0.05–0.12) |
0.020 |
| o-α-syn/t-α-syn | 0.14 (0.09–0.16) |
0.07 (0.06–0.13) |
0.059 |
All data are presented as median (inter-quartile range). τT: total tau protein; Aβ42: amyloid beta with 42 amin acids; τP-181: phosphorylated tau protein at Ser181; a-syn: total a-synuclein; pS129-a-syn: phosphorylated a-syn at Ser 129; ο-α-syn: a synuclein oligomers with syn-O2 as capture antibody; *: analysis of covariance, after log-transformation, with sex, age and disease duration as covariates; ‡: independent samples Kruskal-Wallis test.