Table 2.
Significant Pearsons correlations between clinical variables and circulating miRNAs.
| miR-29a-3p | miR-134-5p | miR-16-5p | miR-122-5p | |
|---|---|---|---|---|
| Age a | 0.133 | 0.114 | 0.203 * | 0.077 |
| 1h glucose a | 0.191 * | 0.101 | 0.256 *,b | 0.136 |
| 2h glucose b | 0.266 * | 0.226* | 0.345 ** | 0.069 |
| HbA1c b | 0.211 | 0.044 | 0.259 * | 0.016 |
| Matsuda index b | 0.125 | 0.131 | 0.082 | −0.309 * |
| Insulin sensitivity (OGIS) b | −0.040 | 0.016 | −0.054 | −0.437 ** |
| Triglycerides a | −0.088 | −0.106 | −0.197 * | 0.030 |
| Free fatty acids a | 0.186 * | 0.059 | −0.006 | 0.034 |
| HDL cholesterol c | −0.085 | −0.091 | −0.106 | −0.240 * |
| Leptin c | 0.102 | 0.132 | 0.058 | −0.236 * |
| Birthweight | 0.061 | 0.068 | 0.047 | 0.243 * |
| miR-134-5p a | 0.731 *** | - | - | - |
| miR-16-5p a | 0.487 *** | 0.181 | - | - |
| miR-122-5p a | 0.173 | 0.050 | 0.343 *** | - |
Table 2 Association between clinical variables and circulating miRNAs. Clinical variables were measured at baseline a, at 24–28 week b, or at 35–37 week c and correlated with baseline miRNA levels. Pearson correlation coefficients are listed. Statistically significant values are in bold with p values, * p < 0.05, ** p < 0.01 and *** p < 0.001. Levels of miRNAs were normalized against the geometric mean of snRNA U6, ath-miR-159 and c.el.miR-39 and logarithmic transformed prior to analysis. Covariate were maternal age and BMI, gestational age and offspring sex.