Table 5.

The diagnostic benefit of thyroglobulin values in the prediction of therapeutic response (by ROC analysis).

Tumor Free vs. Uncertain + Incomplete Biochemical Response + Structural Disease at the End of Follow-Up
Thyroglobulin	AUC	p-Value	Cut-Off (ng/mL)	Sens%	Spec%	PPV%	NPV%	DA%
Postoperative	0.825	<0.001	20.1	75.7	75.5	75.5	75.7	75.6
After 1 year	0.897	<0.001	0.45	78.4	93.5	92.3	81.2	86.0
The lowest	0.868	<0,001	<0.1	74.3	97.8	97.1	79.2	86.1
The highest	0.911	<0.001	0.85	86.4	82.0	82.8	85.8	84.2
Tumor Free + Uncertain vs. Incomplete Biochemical Response + Structural Disease at the End of Follow-Up
Thyroglobulin	AUC	p-Value	Cut-Off (ng/mL)	Sens%	Spec%	PPV%	NPV%	DA%
Postoperative	0.838	<0.001	41.2	71.4	89.0	86.7	75.7	80.2
After 1 year	0.928	<0.001	0.85	87.8	90.9	90.6	88.2	89.4
The lowest	0.919	<0.001	0.45	85.7	96.3	95.9	87.1	91.0
The highest	0.945	<0.001	3.35	85.7	92.1	91.6	86.6	88.9
Tumor Free + Uncertain + Incomplete Biochemical Response vs. Structural Disease at the End of Follow-Up
Thyroglobulin	AUC	p-Value	Cut-Off (ng/mL)	Sens%	Spec%	PPV%	NPV%	DA%
Postoperative	0.857	<0.001	34.6	85.3	82.7	83.1	84.9	84.0
After 1 year	0.933	<0.001	0.85	91.2	84.9	85.8	90.6	88.1
The lowest	0.909	<0.001	0.75	85.3	92.7	92.1	86.3	89.0
The highest	0.958	<0.001	7.7	91.2	92.2	92.1	91.3	91.7

AUC: area under the curve; PPV: positive predictive value; NPV: negative predictive value; DA: diagnostic accuracy.