Table 1.
Postulated effects of cannabidiol (CBD) on the receptors [52,54,55]. Abbrev.: A—adenosine, TRPA1—transient receptor potential ankyrin 1, TRPV—transient potential vanilloid receptor, CB—cannabinoid, GPR—G protein-coupled receptor, and PPAR—peroxisome proliferator-activated receptor, 5-HT – serotonin receptor, TRPM – transient receptor potential melastatin.
| Receptor | CBD Activity | Receptor | CBD Activity |
|---|---|---|---|
| CB1 | Noncompetitive antagonist, negative allosteric modulator | 5-HT1A | Agonist |
| CB2 | Antagonist, inverse agonist | 5-HT2A | Partial agonist |
| GPR55 | Antagonist | 5-HT3A | Antagonist |
| GPR18 | Antagonist | A1A | Agonist |
| PPAR-γ | Agonist | channel TRPV1, TRPV2 | Agonist |
| TRPM8 | Antagonist | TRPA1 | Antagonist |
| α1, α3 glycine receptors | Agonist |