Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 14;9(1):52. doi: 10.3390/vaccines9010052

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Predicted B-cell epitopes in NoV GII.4 variants and their evolutionary pattern. (A) Linear B-cell epitopes were predicted within norovirus Sydney GII.4 capsid protein using IEDB, Epitopia27 and BepiPred prediction tools: epitopes with antigenicity index higher that 0.4 were considered as antigen. NoV crystal structure (1IHM) was taken from protein data bank and structure was generated with chimera tool. (B) Evolutionary pattern of the predicted linear and conformation epitopes was determined within the GII4 variants connected with norovirus outbreaks. Yellow and green colors have been used to differentiate closed neighboring conformational epitopes (C) Columns of heterogenecity within P2 domain. Respective variants constituted yearly consensus sequences till they were replaced by the next variant. Positively selected sites are labelled with an asterisk below the columns.