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Molecular docking of NoV capsid protein and HBGA. (A) Predicted HBGA binding sites. Comparing GII.4 variants, two HBGA binding patterns were predicted; each GII.4 variant showed similar binding pattern for the both Lewisa and Lewisb saccharides. (B) 3-D protein structure models of GII.4 capsid proteins from 1987, 2004, 2006 and 2012 are represented along docked pose (zoomed plot) of HBGA with P2 domains.
