Table 5.
Macroscopic and microscopic lesions in aflatoxin poisoning in dogs *.
| Location | Macroscopic Lesions | Microscopic Lesions |
|---|---|---|
| Generalized | Hemorrhagic diathesis, jaundice, and ascites. | |
| Hepatic | Hepatomegaly, uneven surface, pale yellowish discoloration, enhanced lobular pattern, cholestasis, and gallbladder edema. | Hepatocytes with micro and macrovesicular steatosis, cytomegaly, pyknosis, karyorexis, and necrosis. Centrilobular areas with hemorrhage, reticulin, and collagen. Hyperplasia and proliferation of bile ducts. |
| Pulmonary | Atelectasis, congestion, pleural effusion, hydrothorax, and petechiae. | Alveoli with hemorrhage and perivascular edema. |
| Cardiac | Ecchymosis and petechiae in the endocardium and epicardium. Hydropericardium. | |
| Digestive | Edema and congestion in the gastrointestinal lumen, mesenteric lymph nodes and pancreas. | Necrosis with mononuclear infiltration in the mucosa. |
| Splenic | Splenomegaly | Diffuse perivascular edema and red pulp with hemorrhages and erythrophagocytosis. |
| Renal | Dark red coloration with subcapsular depressions and multifocal hemorrhages. | Fluid accumulation in Bowman’s space and glomerular basement membrane thickening. Multifocal vascular congestion in the interstitial tissue of the renal medulla and pelvis. Degeneration, ectasia, and necrosis of the proximal and distal tubular epithelium. |