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(a) Histone lysine acetylation by histone lysine acetyltransferases (KATs). (b) View of the crystal structure of the tKAT2A-H3K14-CoASH complex (tKAT2A: cyan; CoASH: pink; H3K14: green) (PDB: 1QSN). (c) View of the crystal structure of the KAT8-AcCoA complex (KAT8: gray; AcCoA: pink) (PDB: 2GIV), highlighting the two catalytically relevant residues C316 and E350.
