Figure 5.

Functions of molecular chaperones in regulating cardiomyocyte protein quality. The major molecular chaperone families and their roles in the maintenance of cardiomyocyte protein quality control are illustrated. Hsp70, Hsp90, sHsp and Hsp40 are particularly important in protein folding, while Hsp60 facilitates protein translocation and BAG3 facilitates the degradation of misfolded proteins.