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Activation of NLRC4 and NLRP3. (A) Cryo-EM structure of leucine-rich repeats (LRR) and NACHT domains of NLRP3 in association with NEK7 (PDB ID: 6NPY) [118]. The ribbon diagram is generated with PyMOL molecular graphics software; (B) structural organization and activation of NLRC4. This image is adapted from Figure 2C of [137]; (C) modelling of NLRP3 active conformation and NLRP3 dimer formation in association with NEK7. This image is adapted from Figure 5A,B of [118].
