| ADP | Adenosine diphosphate |
| AIM2 | Absent in melanoma 2 |
| ALRs | (AIM2)-like receptors |
| Apaf-1 | Apoptotic protease activating factor |
| ASC | Apoptosis-associated speck-like protein containing a caspase-activation and recruitment domain (CARD) |
| Bcl | B-cell lymphoma |
| BIR | Baculovirus IAP (inhibitor of apoptosis protein) repeat |
| BMDCs | Bone marrow derived dendritic cells |
| BRCA1 | Breast cancer type-1 |
| BRCC3 | BRCA1/BRCA2- containing complex, subunit 3 |
| c-FLIP | FLICE-like inhibitory protein |
| CAPS | Cryopyrin-associated periodic syndrome |
| CARD | Caspase-activation and recruitment domain |
| CDL | CARD domain linker |
| CIAS1 | cold induced autoinflammatory syndrome 1 |
| CLR | C-type lectin receptor |
| COPs | CARD-only proteins |
| COS-1 | CV-1 in Origin with SV40 genes |
| COVID-19 | Coronavirus disease 2019 |
| DAMPs | Danger-associated molecular patterns |
| DD | Death domain |
| DEDs | Death-effector domain |
| DEFCAP | Death Effector Filament-forming Ced-4-likeApoptosis Protein |
| DUBs | Deubiquitinating enzyme |
| EM | Electron microscopy |
| FADD | Fas-associated protein with death domain |
| FBXL2 | F-box L |
| FBXO3 | F-box O3 |
| FLICE | Caspase-8/FADD-like IL-1β-converting enzyme |
| FP | Fluorescence polarization |
| FRET | Fluorescence resonance energy transfer |
| GFP | Green-fluorescent protein |
| GLMN | Glomulin |
| GSDMD | Gasdermin D |
| HD | helical domain |
| HDAC | Histone deacetylases |
| HIN | Hematopoietic, Interferon-inducible, Nuclear localization |
| IAPs | Inhibitor of apoptosis proteins |
| IC50 | Inhibitory concentration |
| ICE | Interleukin 1β-converting enzyme |
| ICE | Interleukin-1beta converting enzyme |
| IFI16 | Gamma-interferon-inducible protein |
| IFN | Interferon |
| IKK-γ | Inhibitor of nuclear factor kappa-B kinase subunit gamma |
| IL | Interleukin |
| INCA | Inhibitors of NFAT-calcineurin association |
| IPAF | Ice protease activating factor |
| IRF4 | Interferon regulatory factor |
| ITC | Isothermal titration calorimetry |
| JNK | Jun N-terminal kinase |
| LPS | Lipopolysaccharide |
| LRRs | Leucine- rich repeat |
| LTA | Lipoteichoic acid |
| LUBAC | linear ubiquitin chain assembly complex |
| MALS | Multiangle light scattering |
| MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
| MAPK | Mitogen-activated protein kinase |
| MAPL | Mitochondria-associated protein ligase |
| MARCH7 | Membrane associated ring finger (C3HC4) 7 |
| MAVS | Mitochondrial antiviral-signaling protein |
| MBP | Maltose-binding protein |
| MLKL | Mixed lineage kinase domain like pseudokinase |
| MNDA | Myeloid cell nuclear differentiation antigen |
| MSU | Monosodium urate |
| Mul1 | Mitochondrial E3 Ubiquitin Protein Ligase 1 |
| NAIP | NLR family of apoptosis inhibitory protein |
| NALP | NACHT, LRR and PYD domains-containing proteins |
| NBD | Nucleotide binding domain |
| NEK7 | NIMA-related kinase 7 |
| NEMO | NF-kappa-B essential modulator |
| NF-κB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
| NLRC | NLR family CARD domain-containing protein |
| NLRP | Nod-like receptor protein |
| NLRP3 | NLR family pyrin domain containing 3 |
| NLRs | NOD-like receptors |
| NMR | Nuclear magnetic resonance |
| NOD | Nucleotide-binding oligomerization domain |
| OB | Oligonucleotide/oligosaccharide binding) |
| PAMPs | Pathogen-associated molecular patterns |
| PAO | Phenylarsine oxide |
| PKA | protein kinase A |
| PKD | protein kinase D |
| POPs | PYD-only proteins |
| PP2A | protein phosphatase 2 A |
| PRRs | Pathogen recognition receptors |
| PTM | Post-translation modifications |
| PTPase | Protein tyrosine phosphatase |
| PTPN22 | Protein tyrosine phosphatase nonreceptor type 22 |
| PYCARD | PYD and CARD domain-containing |
| PYD | Pyrin domain |
| PYHIN | Pyrin + HIN |
| PYPAF1 | PYRIN-containing APAF1-like protein 1 |
| RAIDD | RIP-associated ICH1/CED3-homologous protein with a death domain |
| RICK | RIP-like interacting CLARP kinase |
| RIP2 | Receptor-interacting protein 2 |
| RMSD | Root-mean-square deviation |
| RNO | Regulated by nitric oxide |
| ROS | Reactive oxygen species |
| SARS-Cov-2 | Severe acute respiratory syndrome coronavirus 2 |
| SCF | Skp-Cullin-F box |
| SEC | Size-exclusion chromatography |
| SHARPIN | Shank-associated RH domain-interacting protein |
| STAT1 | Signal transducer and activator of transcription |
| TEV | Tobacco etch virus. |
| TH2 | T-helper cell type 2 |
| TLR | Toll-like receptors |
| TMS | Target of Methylation-induced Silencing-1 |
| TNF | Tumor necrosis factor |
| TPA | 12-O-tetradecanoylphorbol-13-acetate |
| TRAF3 | TNF receptor associated factor 3 |
| TRIF | TIR-domain-containing adapter-inducing interferon-β |
| TRIM | Tripartite motif |
| WHD | winged helical domain |
| WHO | World health organization |