ADP |
Adenosine diphosphate |
AIM2 |
Absent in melanoma 2 |
ALRs |
(AIM2)-like receptors |
Apaf-1 |
Apoptotic protease activating factor |
ASC |
Apoptosis-associated speck-like protein containing a caspase-activation and recruitment domain (CARD) |
Bcl |
B-cell lymphoma |
BIR |
Baculovirus IAP (inhibitor of apoptosis protein) repeat |
BMDCs |
Bone marrow derived dendritic cells |
BRCA1 |
Breast cancer type-1 |
BRCC3 |
BRCA1/BRCA2- containing complex, subunit 3 |
c-FLIP |
FLICE-like inhibitory protein |
CAPS |
Cryopyrin-associated periodic syndrome |
CARD |
Caspase-activation and recruitment domain |
CDL |
CARD domain linker |
CIAS1 |
cold induced autoinflammatory syndrome 1 |
CLR |
C-type lectin receptor |
COPs |
CARD-only proteins |
COS-1 |
CV-1 in Origin with SV40 genes |
COVID-19 |
Coronavirus disease 2019 |
DAMPs |
Danger-associated molecular patterns |
DD |
Death domain |
DEDs |
Death-effector domain |
DEFCAP |
Death Effector Filament-forming Ced-4-likeApoptosis Protein |
DUBs |
Deubiquitinating enzyme |
EM |
Electron microscopy |
FADD |
Fas-associated protein with death domain |
FBXL2 |
F-box L |
FBXO3 |
F-box O3 |
FLICE |
Caspase-8/FADD-like IL-1β-converting enzyme |
FP |
Fluorescence polarization |
FRET |
Fluorescence resonance energy transfer |
GFP |
Green-fluorescent protein |
GLMN |
Glomulin |
GSDMD |
Gasdermin D |
HD |
helical domain |
HDAC |
Histone deacetylases |
HIN |
Hematopoietic, Interferon-inducible, Nuclear localization |
IAPs |
Inhibitor of apoptosis proteins |
IC50
|
Inhibitory concentration |
ICE |
Interleukin 1β-converting enzyme |
ICE |
Interleukin-1beta converting enzyme |
IFI16 |
Gamma-interferon-inducible protein |
IFN |
Interferon |
IKK-γ |
Inhibitor of nuclear factor kappa-B kinase subunit gamma |
IL |
Interleukin |
INCA |
Inhibitors of NFAT-calcineurin association |
IPAF |
Ice protease activating factor |
IRF4 |
Interferon regulatory factor |
ITC |
Isothermal titration calorimetry |
JNK |
Jun N-terminal kinase |
LPS |
Lipopolysaccharide |
LRRs |
Leucine- rich repeat |
LTA |
Lipoteichoic acid |
LUBAC |
linear ubiquitin chain assembly complex |
MALS |
Multiangle light scattering |
MALT1 |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
MAPK |
Mitogen-activated protein kinase |
MAPL |
Mitochondria-associated protein ligase |
MARCH7 |
Membrane associated ring finger (C3HC4) 7 |
MAVS |
Mitochondrial antiviral-signaling protein |
MBP |
Maltose-binding protein |
MLKL |
Mixed lineage kinase domain like pseudokinase |
MNDA |
Myeloid cell nuclear differentiation antigen |
MSU |
Monosodium urate |
Mul1 |
Mitochondrial E3 Ubiquitin Protein Ligase 1 |
NAIP |
NLR family of apoptosis inhibitory protein |
NALP |
NACHT, LRR and PYD domains-containing proteins |
NBD |
Nucleotide binding domain |
NEK7 |
NIMA-related kinase 7 |
NEMO |
NF-kappa-B essential modulator |
NF-κB |
Nuclear factor kappa-light-chain-enhancer of activated B cells |
NLRC |
NLR family CARD domain-containing protein |
NLRP |
Nod-like receptor protein |
NLRP3 |
NLR family pyrin domain containing 3 |
NLRs |
NOD-like receptors |
NMR |
Nuclear magnetic resonance |
NOD |
Nucleotide-binding oligomerization domain |
OB |
Oligonucleotide/oligosaccharide binding) |
PAMPs |
Pathogen-associated molecular patterns |
PAO |
Phenylarsine oxide |
PKA |
protein kinase A |
PKD |
protein kinase D |
POPs |
PYD-only proteins |
PP2A |
protein phosphatase 2 A |
PRRs |
Pathogen recognition receptors |
PTM |
Post-translation modifications |
PTPase |
Protein tyrosine phosphatase |
PTPN22 |
Protein tyrosine phosphatase nonreceptor type 22 |
PYCARD |
PYD and CARD domain-containing |
PYD |
Pyrin domain |
PYHIN |
Pyrin + HIN |
PYPAF1 |
PYRIN-containing APAF1-like protein 1 |
RAIDD |
RIP-associated ICH1/CED3-homologous protein with a death domain |
RICK |
RIP-like interacting CLARP kinase |
RIP2 |
Receptor-interacting protein 2 |
RMSD |
Root-mean-square deviation |
RNO |
Regulated by nitric oxide |
ROS |
Reactive oxygen species |
SARS-Cov-2 |
Severe acute respiratory syndrome coronavirus 2 |
SCF |
Skp-Cullin-F box |
SEC |
Size-exclusion chromatography |
SHARPIN |
Shank-associated RH domain-interacting protein |
STAT1 |
Signal transducer and activator of transcription |
TEV |
Tobacco etch virus. |
TH2 |
T-helper cell type 2 |
TLR |
Toll-like receptors |
TMS |
Target of Methylation-induced Silencing-1 |
TNF |
Tumor necrosis factor |
TPA |
12-O-tetradecanoylphorbol-13-acetate |
TRAF3 |
TNF receptor associated factor 3 |
TRIF |
TIR-domain-containing adapter-inducing interferon-β |
TRIM |
Tripartite motif |
WHD |
winged helical domain |
WHO |
World health organization |