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. 2021 Jan 17;22(2):879. doi: 10.3390/ijms22020879

Figure 1.

Figure 1

Telomerase-specific conditionally-replicating oncolytic adenoviruses. (A) OBP-301 is driven by the hTERT promoter for preferential replication in cancer cells. OBP-301 replicates preferentially in cancer cells that have high expression of telomerase. OBP-301 induces cancer-specific cell death after replication. (B) OBP-401 contains a cassette comprising of a CMV promoter and green fluorescent protein (GFP) gene. OBP-401 preferentially labels cancer cells with GFP and then kills them, depending on the multiphcity of infection. (C) OBP-301 with KillerRed contains a cassette comprising the CMV promoter and KillerRed gene. This virus preferentially labels cancer cells with KillerRed. OBP-301 with KillerRed has a dual function of adenovirus-mediated cancer-cell killing and PDT.