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. 2021 Jan 17;22(2):879. doi: 10.3390/ijms22020879

Figure 3.

Figure 3

OBP-401-GFP mediated fluorescence-guided surgery (FGS) with preservation of function. (A) FGS for glioblastoma (GBM) with OBP-401-mediated bright GFP tumor labeling and oncolysis. Whole-tumor imaging with an orthotopic GBM mouse model demonstrated that low-dose OBP-401 labels GBM tumors with GFP and clearly highlights the margin between the GBM and normal brain tissue, which enables FGS with partial loss of brain function. High-dose OBP-401 shrinks the GBM tumor, then enables effective FGS with preservation of function. (B) FGS for soft tissue sarcoma (STS) with OBP-401-mediated bright GFP tumor labeling and oncolysis. Whole-tumor imaging with an orthotopic STS mouse model demonstrated that low-dose OBP-401 labels STS tumors with GFP, clearly highlights the margin between the STS tumor and normal muscle or fat tissue, and consequently enables FGS partly with partial loss of motor function. High-dose OBP-401 shrinks the STS tumor, then enables effective FGS with preservation of motor function.