Table 1.
Distribution of baseline characteristics of chronic lymphocytic leukemia patients according to the Charlson comorbidity index score.
| Clinical Characteristics | Charlson Comorbidity Index (CCI) | ||||||
|---|---|---|---|---|---|---|---|
| Total | Absence of Comorbidity | Low Risk | Moderate Risk | High Risk | Unknown | ||
| 0 | 1–2 | 3–4 | >4 | p-Value | |||
| n (%) a | n (%) a | n (%) a | n (%) a | n (%) a | n (%) a | ||
| Total | 400 (100.0) | 20 (5.0) | 86 (21.5) | 151 (37.7) | 118 (29.5) | 25 (6.2) | |
| Age | |||||||
| Mean (SD) | 70.8 (12.2) | 43.6 (5.5) | 59.41(5.6) | 73.11 (7.2) | 80.58 (7.7) | 70.96 (11.8) | <0.001 |
| Median (Range) | 72 (62–80) | 46 (39.7–48) | 59 (55–63.7) | 74 (69–78) | 83 (75.2–86) | 69 (60–79) | |
| Gender | |||||||
| Male | 230 (57.5) | 9 (45.0) | 46 (53.5) | 84 (55.6) | 74 (62.7) | 17 (68.0) | 0.342 |
| Female | 170 (42.5) | 11 (55.0) | 40 (46.5) | 67 (44.4) | 44 (37.3) | 8 (32.0) | |
| Age group | |||||||
| <65 | 122 (30.5) | 20 (100.0) | 65 (75.6) | 22 (14.6) | 5 (4.2) | 10 (40.0) | <0.001 |
| 65–78 | 158 (39.5) | - | 21 (24.4) | 97 (64.2) | 32 (27.1) | 8 (32.0) | |
| >78 | 120 (30.0) | - | - | 32 (21.2) | 81 (68.6) | 7 (28.0) | |
| Rai stage | |||||||
| 0 | 227 (56.7) | 12 (60.0) | 57 (66.3) | 85 (56.3) | 68 (57.6) | 5 (20.0) | <0.001 |
| I-II | 60 (15.0) | 5 (25.0) | 15 (17.4) | 29 (19.2) | 11 (9.3) | - | |
| III-IV | 35 (8.7) | 2 (10.0) | 6 (7.0) | 12 (7.9) | 15 (12.7) | - | |
| Unknown | 78 (19.5) | 1 (5.0) | 8 (9.3) | 25 (16.6) | 24 (20.3) | 20 (80.0) | |
| Period of diagnostic | |||||||
| 2008–2010 | 141 (35.2) | 6 (30.0) | 27 (31.4) | 54 (35.8) | 45 (38.1) | 9 (36.0) | 0.320 |
| 2011–2013 | 136 (34.0) | 12 (60.0) | 27 (31.4) | 51 (33.8) | 37 (31.4) | 9 (36.0) | |
| 2014–2016 | 123 (30.7) | 2 (10.0) | 32 (37.2) | 46 (30.5) | 36 (30.5) | 7 (28.0) | |
a Except when specified.