Table 3.
Univariate and multivariate analysis of mortality (overall, CLL-related, and CLL-unrelated) in patients with chronic lymphocytic leukemia in Girona (2008–2016).
| Variable | Univariate Analysis | Multivariate Analysis | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Overall Mortality (n = 400) | CLL-Related Mortality (n = 86) | CLL-Unrelated Mortality (n = 69) | Overall Mortality (n = 400) | CLL-Related Mortality (n = 86) | Unrelated to CLL Mortality (n = 69) | ||||||||
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | |||
| Sex | Female | 170 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| Male | 230 | 1.28 (0.94; 1.75) | 0.118 | 0.85 (0.54–1.31) | 0.457 | 1.11 (0.68–1.81) | 0.680 | 1.38 (1.01; 1.90) | 0.042 | 0.81 (0.47; 1.39) | 0.447 | 1.18 (0.70–2.01) | 0.529 | |
| Age (y) | <65 | 122 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 65–78 | 158 | 8.45 (5.18; 13.78) | <0.001 | 2.53 (1.17–5.46) | 0.018 | 1.42 (0.60–3.34) | 0.426 | 2.72 (1.59; 4.66) | <0.001 | 2.16 (0.92;5.09) | 0.078 | 1.54 (0.57–4.16) | 0.391 | |
| >78 | 120 | 2.75 (1.65; 4.58) | <0.001 | 2.78 (1.34–5.78) | 0.006 | 1.37 (0.60–3.15) | 0.455 | 9.96 (5.86; 16.92) | <0.001 | 2.20 (0.94; 5.13) | 0.068 | 2.05 (0.76–5.51) | 0.157 | |
| p-trend 1 | <0.001 | <0.001 | 0.07 | <0.001 | 0.015 | 0.396 | ||||||||
| Rai stage | 0 | 227 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| I-II | 60 | 1.49 (0.97; 2.31) | 0.067 | 0.61 (0.34–1.09) | 0.094 | 0.66 (0.28–1.59) | 0.361 | 1.91 (1.23–2.96) | 0.004 | 0.75 (0.39; 1.41) | 0.366 | 1.13 (0.44–2.91) | 0.804 | |
| III-IV | 35 | 2.68 (1.68; 4.27) | <0.001 | 1.04 (0.55–1.97) | 0.901 | 1.83 (0.87-3.84) | 0.111 | 4.17 (2.56; 6.80) | <0.001 | 1.18 (0.57; 2.44) | 0.650 | 8.24 (3.26–20.83) | <0.001 | |
| Unknown | 78 | 2.17 (1.47; 3.18) | <0.001 | 1.70 (0.96–3.02) | 0.069 | 1.71 (0.95–3.06) | 0.072 | 1.95 (1.25; 3.04) | 0.003 | 1.82 (0.79; 4.22) | 0.159 | 1.56 (0.79–3.09) | 0.202 | |
| p-trend 1 | 0.002 | 0.06 | 0.2 | <0.001 | 0.428 | <0.001 | ||||||||
| Period of diagnosis | 2008–2010 | 141 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 2011–2013 | 136 | 1.02 (0.73; 1.42) | 0.900 | 1.15 (0.72–1.84) | 0.567 | 2.77 (1.52–5.04) | <0.001 | 1.35 (0.96; 1.91) | 0.088 | 1.13 (0.66–1.95) | 0.651 | 3.71 (1.95–7.07) | <0.001 | |
| 2014–2016 | 123 | 0.50 (0.31; 0.81) | 0.004 | 1.80 (0.86–3.76) | 0.121 | 5.06 (2.33–10.98) | <0.001 | 0.65 (0.39; 1.07) | 0.092 | 1.04 (0.37–2.88) | 0.946 | 9.95 (4.10–24.12) | <0.001 | |
| p-trend 1 | 0.1 | 0.08 | 0.003 | 0.765 | 0.003 | <0.001 | ||||||||
| CCI | 0 | 20 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| ≥1 | 355 | 5.82 (1.44-23.49) | 0.013 | 1.28 (0.17–9.18) | 0.815 | 2.83 (0.39–20.72) | 0.305 | 2.05 (0.47–8.90) | 0.340 | 0.62 (0.07–5.30) | 0.660 | 8.67 (0.87–85.96) | 0.065 | |
| Unknown | 25 | 10.08 (2.30-44.42) | 0.002 | 1.81 (0.22–14.55) | 0.576 | 8.34 (0.89–78.36) | 0.063 | 4.11 (0.85–19.90) | 0.078 | 0.50 (0.05–5.20) | 0.560 | 68.08 (4.73–980.51) | 0.002 | |
| CCI continuous | 375 | 1.45 (1.34-1.57) | <0.001 | 1.19 (1.04–1.37) | 0.01 | 1.21 (1.05–1.39) | 0.01 | 1.16 (1.01–1.33) | 0.034 | 0.96 (0.77–1.20) | 0.717 | 1.27 (1.06–1.53) | 0.01 | |
CLL—chronic lymphocytic leukemia; 95% CI, 95% confidence interval; CCI—Charlson comorbidity index; HR—hazard ratio. 1 p-value of the Cox proportional model fitted with the ordinal variable as continuous to test for the lineal trend (the unknown category was excluded from the calculation).