Table 2.
Hydrodynamic diameter was measured by batch-mode DLS (intensity-based mean of the most prominent peak) (Dh) and in flow mode by AF4-DLS (Z-average at peak maximum) (Dh *). The Stokes diameter (DS) was measured by analytical ultracentrifugation. Zeta-potential and mobility were also determined by ELS. Values are reported as an average of three measurements. SD is reported in brackets. ND: not determined. Monodisperse liposomes in the nano-size range are highlighted in bold.
| Liposome | Diameter (nm) | PDI | Zeta-Potential (mV) | Mobility (µm cm/Vs) | ||
|---|---|---|---|---|---|---|
| Dh | Dh * | DS | ||||
| F10102 |
98.9
(±26.2) |
92.2
(±8.8) |
96.5 | 0.05 |
−5.90
(±1.92) |
−0.40
(±0.14) |
| F10103 |
104.2
(±28.0) |
93.4
(±10.0) |
93.9 | 0.06 |
−11.90
(±2.20) |
−0.90
(±0.16) |
| F20103A |
115.1
(±31.0) |
105.6
(±12.2) |
90.1 | 0.06 |
−16.60
(±6.35) |
−1.20
(±0.07) |
| F20104A |
103.7
(±27.4) |
96.4
(±9.8) |
93.9 | 0.05 |
−11.80
(±2.09) |
−0.80
(±0.15) |
| F50102 | 98.2 (±50.1) |
ND | ND | 0.36 | +4.10 (±0.39) |
+0.30 (±0.03) |
| F50105 | 929.2 (±119.3) |
ND | ND | 0.49 | −8.10 (±3.40) |
−0.60 (±0.26) |
| F70101C-NH | 552.3 (±79.1) |
ND | ND | 0.59 | −7.50 (±0.01) |
−0.50 (±0.01) |
| F70101-NH | 1154.4 (±334.2) |
ND | ND | 0.54 | −7.20 (±0.72) |
−0.50 (±0.05) |