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. Author manuscript; available in PMC: 2021 Jan 25.
Published in final edited form as: J Med Chem. 2020 Sep 27;63(19):10984–11011. doi: 10.1021/acs.jmedchem.0c00916

Figure 2.

Figure 2.

Crystal structure of LDHA bound to inhibitor 23 (A, pdb code 6Q0D) and 52 (B, pdb code 6Q13). LDHA is shown in ribbon (blue) and key residues in the active site are shown in green. Small-molecule inhibitors are shown in sticks with salmon- and magenta-colored carbons.