Scheme 2.

Syntheses of Analogues 10–32 and 36–89^a

^aReagents and conditions: (a) [P(t-Bu)₃]Pd(crotyl)Cl, DABCO, dioxane, RT, and 1–12 h; (b) [DTBN_pP]Pd(crotyl)Cl, DABCO, dioxane, 60 °C, and 12 h; (c) SPhosPd(crotyl)Cl, K₃PO₄, dioxane/H₂O, 100 °C, and 0.5 h; (d) LiOH, THF/MeOH/H₂O, and 1 h; and (e) CsF, THF–EtOH, RT, and 2 h.