Table 5.
Analysis of non-syndromic cleft lip/palate risk related to the rs560426 polymorphism according to ethnicity and source of controls.
| Variable (N) | G vs. A | GG vs. AA | AG vs. AA | AG + GG vs. AA | GG vs. AA + AG |
|---|---|---|---|---|---|
| OR (95%CI), I2 (%), Ph | OR (95%CI), I2 (%), Ph | OR (95%CI), I2 (%), Ph | OR (95%CI), I2 (%), Ph | OR (95%CI), I2 (%), Ph | |
| Overall (12) | 1.01 (0.88, 1.15), 72, <0.0001 | 1.08 (0.79, 1.47), 77, <0.00001 | 0.93 (0.73, 1.16), 76, <0.00001 | 0.89 (0.70, 1.14), 81, <0.00001 | 1.08 (0.91, 1.26), 36, 0.10 |
| Ethnicity | |||||
| Asian (5) | 1.13 (1.01, 1.27), 0, 0.59 | 1.53 (1.01, 2.31), 62, 0.03 | 1.08 (0.92, 1.26), 35, 0.19 | 1.13 (0.97, 1.32), 10, 0.35 | 1.30 (1.03, 1.63), 27, 0.24 |
| European Descent (3) | 0.82 (0.63, 1.08), 71, 0.03 | 0.67 (0.42, 1.09), 64, 0.06 | 0.72 (0.36, 1.45), 88, 0.0002 | 0.55 (0.34, 0.88), 79, 0.009 | 0.85 (0.67, 1.07), 0, 0.98 |
| Mixed (4) | 1.00 (0.76, 1.31), 79, 0.003 | 0.99 (0.59, 1.68), 78, 0.004 | 0.92 (0.60, 1.42), 76, 0.006 | 0.94 (0.60, 1.49), 81, 0.001 | 1.07 (0.87, 1.30), 41, 0.17 |
| Source of Controls | |||||
| Hospital-Based (6) | 0.94 (0.86, 1.03), 80, 0.0001 | 0.83 (0.69, 1.01), 80, 0.0002 | 0.87 (0.76, 1.01), 84, <0.00001 | 0.89 (0.78, 1.02), 85, <0.00001 | 0.98 (0.83, 1.15), 57, 0.04 |
| Population-Based (6) | 1.07 (0.91, 1.26), 52, 0.06 | 1.29 (0.86, 1.94), 66, 0.01 | 1.02 (0.76, 1.36), 60, 0.03 | 0.91 (0.62, 1.33), 80, 0.0002 | 1.18 (0.97, 1.44), 0, 0.63 |
Bold numbers mean statistically significant (p < 0.05). Ph indicates Pheterogeneity. Abbreviations: OR, odds ratio; CI, confidence interval. “N” shows the number of studies.