Table 7.

Meta-regression analysis based on publication year for association between rs560426 and rs481931 polymorphisms and the risk of non-syndromic cleft lip/palate.

Variable	Polymorphism		Allele	Homozygote	Heterozygote	Recessive	Dominant
Publication Year	rs560426	R	0.025	0.047	0.113	0.172	0.075
		Adjusted R2	−0.099	−0.098	−0.086	−0.068	−0.094
		P	0.937	0.884	0.726	0.593	0.816
	rs481931	R	0.406	0.456	0.243	0.388	0.495
		Adjusted R2	−0.044	0.010	−0.176	−0.062	0.057
		P	0.424	0.364	0.643	0.447	0.318
Number of Participants	rs560426	R	0.098	0.410	0.171	0.118	0.036
		Adjusted R2	−0.089	0.085	−0.068	−0.085	−0.099
		P	0.761	0.185	0.594	0.714	0.912
	rs481931	R	0.953	0.913	0.810	0.650	0.814
		Adjusted R2	0.886	0.793	0.570	0.279	0.579
		P	0.003	0.011	0.051	0.162	0.049

R: Correlation coefficient. Bold numbers mean statistically significant (p < 0.05).