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Effect of PEG-BHD1028 on food intake and weight loss. (A) The amount of food intake after the administration of PEG-BHD1028 was relatively consistent during the testing period. (B) Bodyweight of the 25 and 50 μg/Kg groups were significantly decreased compared to the control groups from day 15 (p ≤ 0.05 and p ≤ 0.01 on day 21) and 5 μg/Kg group from day 21 (p ≤ 0.05). Each point represents the mean of five animals ± S.E. ** p ≤ 0.01, * p ≤ 0.05 vs. control.
