Table 1.
Comparison between studies showing allo-SCT as consolidation of the first or subsequent lines of treatment.
| Study | Timing | N° Patients | ORR/CR | Median FU | 2-yr NRM | 5-yr PFS | 5-yr OS | Main Toxicities |
|---|---|---|---|---|---|---|---|---|
| Le Gouill et al. | Salvage | 70 | 95%/89% | 24mo | 32% | ≈25% | ≈25% | GVHD |
| Krüger et al. | First line | 24 | 86%/76% | 2.8yr | ≈67% | ≈73% | Stomatitis, infection, GVHD | |
| Salvage | 15 | 91%/83% | 2.8yr | ≈67% | ≈73% | |||
| Rule et al. | First line | 25 | 92%/60% | 60.5mo | 13% | 56% | 76% | Infection, mucositis, GVHD |
| Fenske et al. | First response | 50 | 48mo | ≈30% | 55% | 62% | ||
| Salvage | 88 | 37mo | ≈25% | 24% | 31% | |||
| Tessoulin et al. | Salvage | 106 | 97%/86% | 45mo | ≈30% | ≈35% | ≈55% | GVHD, infection |