Figure 1.

Transformation of dietary sphinganine into dihydrocermides by the gut microbes. Here, sphinganine alkyne (SAA) was given to mice by oral gavage (five consecutive days), then the fecal content from mice was collected and metabolic consequences of SAA exposure were determined using high-resolution mass spectrometry ion chromatograms. The authors showed a distinct cecal lipidome chromatograms for mice that orally treated with SAA (blue), which contained the alkyne-bearing (A) C15-, (B) C15OH-, (C) C16OH-, (D) C17OH-, (E) C18:2- and (F) C22:2- dihydrocermides. However, these dihydrocermides were absent in treatments with sphinganine (SA, green), vehicle or no treatment (red). Figure adapted from [40], with permission under CC BY 4.0 license.