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. 2021 Jan 15;22(2):844. doi: 10.3390/ijms22020844

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PD-L1 was downregulated by miR-424-5p delivered via EVs. (A) The internalization of EVs into MM231 (upper) and HCC1954 (bottom) cells 24 h after incubation. Scale bar: 20 µm. (B) Relative expression of miR-424-5p in recipient HCC1954 and MM231 were determined via qRT-PCR assay 24 h after EV incubation. (C) Relative mRNA expression of PD-L1 in HCC1954 and MM231 cells was determined via qRT-PCR assay 24 h after EV incubation. PD-L1 protein expression in HCC1954 (D) and MM231 cells (E) was compared by Western blotting 48 h after treatment. * p < 0.05.