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. 2021 Jan 16;26(2):448. doi: 10.3390/molecules26020448

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The position of natural products implicated in anti-HCoV research. (a) Distribution of entities (extracts, NPs, Nature derived molecules) subjected to anti-HCoV assays (cell based or viral enzyme inhibition), in a total of 326 experiments corresponding to 197 entities. “Nature derived” refers to synthetic/semisynthetic NPs with a basic core inspired by NPs. (b) The prevalence of SARS-CoV testing among several NP entities. (c) The distribution of the 168 pure NPs tested in various anti-HCoV assays, with respect to the chemical category. Data derived from Tables S1–S4, Supporting information.