Figure 6.

Schematic summary of the metabolic impact of C. parvum infection on HCT-8 cells cultivated in presence of 2 mM glutamine and 21% oxygen and targets of selected inhibitors. Bold arrows indicate impact on metabolic conversion rates of C. parvum-infected host cells (compare Figure 3). Based on C. parvum-induced alterations of host cell metabolism, the indicated metabolic inhibitors were selected to investigate their potential to inhibit C. parvum infection in HCT-8 cells. LND: lonidamine, MPC: mitochondrial pyruvate carrier, GLS: glutaminase, LDH: lactate dehydrogenase, MCT: monocarboxylate transporter.